CBP-201-207, Rademikibart, COPD

Inclusion Criteria:
*  Physician-diagnosed COPD with duration of ≥12 months.
*  Must have experienced at least 1 COPD exacerbation requiring the use of systemic corticosteroids.
*  Participants in a stable condition must have a documented historical peripheral blood eosinophil count of ≥250 cells/μL and/or FeNO ≥ 25 ppb.
*  Current or former smoker with a history of smoking of ≥10 pack-years.
*  Current acute COPD exacerbation requiring an urgent healthcare visit for treatment.
*  Peripheral blood eosinophil count of ≥300 cells/μL as part of the assessment of the index acute COPD exacerbation.
*  Requires systemic corticosteroids as standard of care treatment in the urgent healthcare setting for the current acute COPD exacerbation.

Exclusion Criteria:
*  Regular use of immunosuppressive medication 12 weeks or 5 half-lives prior to randomization, whichever is longer.
*  Current diagnosis or a history of asthma, according to the Global Initiative for Asthma; or participants with a current diagnosis or history of Asthma COPD Overlap Syndrome.
*  Other respiratory disorders that might compromise the safety of the participant or affect the interpretation of the results.
*  Unstable ischemic heart disease, cardiomyopathy, heart failure (New York Heart Association Class III or IV), uncontrolled hypertension. Cardiac arrhythmias including paroxysmal atrial fibrillation.
*  Transient ischemic attack or stroke \<6 months from Screening Visit; hospitalization for any cardiovascular or cerebrovascular event \<6 months from Screening Visit.
*  Known or suspected history of immunosuppression.
*  History of known immunodeficiency disorder or hepatitis B or C.
*  History of alcohol abuse and/or drug abuse.
*  Recent history of cancer except basal cell carcinoma or in situ carcinoma of the cervix treated with apparent success.
*  Chronic treatment with long-term oxygen therapy (LTOT) or nocturnal oxygen therapy required for \>15 hours a day.
*  Participants on long-term macrolide.
*  Current acute COPD exacerbation for which SoC was started \>48 hours prior to Screening.
*  A recent chest X-ray or computed tomography (CT) scan at Screening reveals evidence of clinically significant abnormalities not believed to be due to the presence of COPD, or a clinically significant pulmonary infection identified by chest X-ray (CT scan).
*  Female participant who is pregnant, lactating or breast-feeding, or has a positive urinary β-hCG test prior to randomization.
*  Receipt of any marketed nonbiologic drug that modulates type 2 cytokines 30 days or 5 half-lives prior to randomization, whichever is longer.
*  Receipt of any marketed or any investigational biologic for COPD or other diseases within 16 weeks or 5 half-lives prior to randomization, whichever is longer.
*  Live, attenuated vaccinations within 4 weeks prior to randomization or planned live, attenuated vaccinations during the trial.
*  Treatment with oral corticosteroids and/or hospitalization for an exacerbation of COPD completed less than 4 weeks prior to randomization. The above inclusion and exclusion criteria are not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.