Overview
Principal investigator
Eligibility criteria
Inclusion Criteria:
* AK on at least one of the following: culture, smear, PCR, shotgun sequencing, biopsy, or confocal microscopy
* Ocular inflammation after 1 month of anti-amoebic treatment, defined as conjunctival, corneal, episcleral, or anterior chamber inflammation
Exclusion Criteria:
* Evidence or history of interstitial keratitis
* Known herpetic keratitis, as determined from history, exam, or microbiological testing
* Known fungal keratitis, as demonstrated from corneal scrapings
* Corneal perforation or impending corneal perforation
* Prior therapeutic keratoplasty for acanthamoeba keratitis
* Unwillingness or inability to follow-up
* No light perception in the affected eye
* Known hypertensive response to steroids
* Corticosteroid allergy
* Concurrent treatment with systemic corticosteroids
* Concurrent granulomatous amoebic encephalitis
* AK on at least one of the following: culture, smear, PCR, shotgun sequencing, biopsy, or confocal microscopy
* Ocular inflammation after 1 month of anti-amoebic treatment, defined as conjunctival, corneal, episcleral, or anterior chamber inflammation
Exclusion Criteria:
* Evidence or history of interstitial keratitis
* Known herpetic keratitis, as determined from history, exam, or microbiological testing
* Known fungal keratitis, as demonstrated from corneal scrapings
* Corneal perforation or impending corneal perforation
* Prior therapeutic keratoplasty for acanthamoeba keratitis
* Unwillingness or inability to follow-up
* No light perception in the affected eye
* Known hypertensive response to steroids
* Corticosteroid allergy
* Concurrent treatment with systemic corticosteroids
* Concurrent granulomatous amoebic encephalitis
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