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A Phase 2 Study of Mosliciguat in PH-ILD

Internal Medicine Pulmonology Heart and Vascular Lung Disease Pulmonary Hypertension Heart Disease Adult Subjects Female Subjects Male Subjects

This is a Phase 2, randomized, double-blind, placebo-controlled, multi-center clinical study to evaluate the safety and efficacy of inhaled mosliciguat in participants with pulmonary hypertension associated with interstitial lung disease (PH-ILD).

MK5475-013

Internal Medicine Pulmonology Heart and Vascular Pulmonary Hypertension Airway Disease Heart Disease Lung Disease Adult Subjects Female Subjects Male Subjects

Researchers are looking for ways to treat pulmonary hypertension (PH) caused by chronic obstructive pulmonary disease (COPD). The goal of the study is to learn if people who take MK-5475 can walk farther in 6 minutes at Week 24 compared to people who take placebo.

A Phase 3, Prospective, Multicenter, Double-blind, Double-dummy, Randomized, Activecontrolled, Parallel-group, Group-sequential, Adaptive, Event-driven Study to Compare Efficacy, Safety, and Tolerability of Macitentan 75 mg Versus Macitentan 10 mg in…

Internal Medicine Pulmonology Pulmonary Hypertension Adult Subjects Female Subjects Male Subjects

The purpose of this study is to demonstrate superiority of macitentan 75 milligrams (mg) in prolonging the time to the first clinical events committee (CEC)-adjudicated morbidity or mortality (M/M) event in participants with symptomatic pulmonary arterial hypertension (PAH) compared to macitentan 10 mg.

ADVANCE Outcomes

Internal Medicine Pulmonology Heart and Vascular Pulmonary Hypertension Heart Disease Adult Subjects Female Subjects Male Subjects

Study ROR-PH-301, ADVANCE OUTCOMES, is designed to assess the efficacy and safety of ralinepag when added to pulmonary arterial hypertension (PAH) standard of care or PAH-specific background therapy in subjects with World Health Organization (WHO) Group 1 PAH.

Smoking Cessation and Functional CT Assessment

Cancer Radiology Pulmonology Heart and Vascular Pulmonary Hypertension Vascular Disease Airway Disease Heart Disease Healthy Subjects Adult Subjects Female Subjects Male Subjects

The investigators will study the effect of pulmonary arterial vasodilation to see if it eliminates indices of persistent lung injury in smokers that are susceptible to emphysema.