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KATALYST-AV: A study to evaluate whether the investigational medicine, ataciguat, slows down the progression of the dysfunction of the aortic valve in adults 50+ with calcific aortic valve stenosis

Internal Medicine Heart and Vascular Valve Disease Adult Subjects

The primary objective of the current study is to determine whether Ataciguat (HMR1766) slows progression of valve calcification in patients with moderate calcific aortic valve stenosis. Secondary and tertiary objectives are to determine whether Ataciguat slows progression of aortic valve function, reduces systemic inflammation, and prevents left ventricular dysfunction in patients with moderate calcific aortic valve stenosis.

GORE CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients with Patent Foramen Ovale (PFO): the REDUCE Post Approval Study

Internal Medicine Neurology Heart and Vascular Stroke Valve Disease Adult Subjects

This study will assess the safety and effectiveness of GORE® CARDIOFORM Septal Occluder in a post approval setting and evaluate the quality of operator education and training and transferability of trial experience to a post-market setting.