Valve Disease

RESTORE Study-Collection of clinical evidence on heart valve safety & performance in subject treated with a redo Transcatheter Aortic Valve Replacement.

Internal Medicine Heart and Vascular Valve Disease Adult Subjects

The purpose of this study is to generate clinical evidence on valve safety and performance in subjects treated by redo Transcatheter Aortic Valve Replacement (TAVR).

KATALYST-AV: A study to evaluate whether the investigational medicine, ataciguat, slows down the progression of the dysfunction of the aortic valve in adults 50+ with calcific aortic valve stenosis

Internal Medicine Heart and Vascular Valve Disease Adult Subjects

The primary objective of the current study is to determine whether Ataciguat (HMR1766) slows progression of valve calcification in patients with moderate calcific aortic valve stenosis. Secondary and tertiary objectives are to determine whether Ataciguat slows progression of aortic valve function, reduces systemic inflammation, and prevents left ventricular dysfunction in patients with moderate calcific aortic valve stenosis.

A prospective, multicenter, randomized, controlled pivotal trial to evaluate the safety and effectiveness of transcatheter mitral valve repair with the Edwards PASCAL Transcatheter Valve Repair System compared to Abbott MitraClip in patients with mitra…

Internal Medicine Heart and Vascular Valve Disease Adult Subjects

Tricuspid Valve Repair (T-TEER) with Edwards PASCAL +Optimal Medical Therapy vs. Optimal Medical Therapy Alone for Severe Tricuspid Valve Regurgitation

Internal Medicine Heart and Vascular Valve Disease Adult Subjects

GORE CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients with Patent Foramen Ovale (PFO): the REDUCE Post Approval Study

Internal Medicine Neurology Heart and Vascular Stroke Valve Disease Adult Subjects

This study will assess the safety and effectiveness of GORE® CARDIOFORM Septal Occluder in a post approval setting and evaluate the quality of operator education and training and transferability of trial experience to a post-market setting.

ACURATE IDE: Transcatheter Replacement of Stenotic Aortic Valve through Implantation of ACURATE in Subjects Indicated for TAVR

Internal Medicine Heart and Vascular Valve Disease Adult Subjects

Evaluation of Transcatheter Aortic Valve Replacement Compared to Surveillance for Patients with Asymptomatic Severe Aortic Stenosis

Internal Medicine Heart and Vascular Valve Disease Adult Subjects

This study will evaluate the safety and effectiveness of the Edwards SAPIEN 3/SAPIEN 3 Ultra Transcatheter Heart Valve (THV) compared with clinical surveillance (CS) in asymptomatic patients with severe, calcific aortic stenosis.

Attention Site Visitor

RESTORE Study-Collection of clinical evidence on heart valve safety & performance in subject treated with a redo Transcatheter Aortic Valve Replacement.

KATALYST-AV: A study to evaluate whether the investigational medicine, ataciguat, slows down the progression of the dysfunction of the aortic valve in adults 50+ with calcific aortic valve stenosis

A prospective, multicenter, randomized, controlled pivotal trial to evaluate the safety and effectiveness of transcatheter mitral valve repair with the Edwards PASCAL Transcatheter Valve Repair System compared to Abbott MitraClip in patients with mitra…

Tricuspid Valve Repair (T-TEER) with Edwards PASCAL +Optimal Medical Therapy vs. Optimal Medical Therapy Alone for Severe Tricuspid Valve Regurgitation

GORE CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients with Patent Foramen Ovale (PFO): the REDUCE Post Approval Study

ACURATE IDE: Transcatheter Replacement of Stenotic Aortic Valve through Implantation of ACURATE in Subjects Indicated for TAVR

Evaluation of Transcatheter Aortic Valve Replacement Compared to Surveillance for Patients with Asymptomatic Severe Aortic Stenosis