Yousef Zakharia | University of Iowa Clinical Research and Trials

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Studies

A phase Ib study of combination of Avelumab and Taxane based chemotherapy in platinum refractory or ineligible metastatic urothelial cancer (AVETAX study)

Cancer Internal Medicine Kidney Cancer Bladder Cancer Adult Subjects Female Subjects Male Subjects

This study evaluates the safety and efficacy of the combination of Avelumab, (a fully human anti-programmed death ligand 1 (PD-L1) IgG1 antibody) in combination with a taxane chemotherapy (docetaxel) in patients with metastatic urothelial cancer who are either ineligible to receive cisplatin based chemotherapy, refractory to cisplatin in first line setting or have disease relapse after receiving cisplatin based chemotherapy within a year in the neoadjuvant or adjuvant setting.