Studies

VX24-KDO-901, PKD1 Gene in ADPKD

Internal Medicine Pediatric Subjects Adult Subjects

The purpose of this study is to estimate the prevalence, demographic, and clinical characteristics of PKD1/2 gene variant groups in the ADPKD population.

A PHASE III, MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF RO7434656, AN ANTISENSE INHIBITOR OF COMPLEMENT FACTOR B, IN PATIENTS WITH PRIMARY IgA NEPHROPATHY AT HIGH RISK OF PROGRESSION

Internal Medicine Nephrology Kidney Disease Adult Subjects

The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of sefaxersen (RO7434656), a novel Antisense Oligonucleotide (ASO) therapy in participants with primary IgA nephropathy (IgAN) who are at high risk of progressive kidney disease despite optimized supportive care.

20220159 Avacopan for ANCA-associated Vasculitis

Internal Medicine Immunology Autoimmune Adult Subjects

The primary objective of this study is to evaluate the long-term safety of avacopan in participants with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).

417-201-00007, Sibeprenlimab, IgAN

Internal Medicine Nephrology Kidney Disease Adult Subjects

This is a phase 3 study to evaluate effects on proteinuria and glomerular filtration rate of sibeprenlimab 400 mg subcutaneously (s.c.) Q 4 weeks in adults with IgAN who are receiving maximally tolerated standard-of-care therapy.