Studies

A PHASE III, MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF RO7434656, AN ANTISENSE INHIBITOR OF COMPLEMENT FACTOR B, IN PATIENTS WITH PRIMARY IgA NEPHROPATHY AT HIGH RISK OF PROGRESSION

Internal Medicine Nephrology Kidney Disease Adult Subjects

The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of RO7434656, a novel Antisense Oligonucleotide (ASO) therapy in participants with primary IgA nephropathy (IgAN) who are at high risk of progressive kidney disease despite optimized supportive care.

20220159 Avacopan for ANCA-associated Vasculitis

Internal Medicine Immunology Autoimmune Adult Subjects

The primary objective of this study is to evaluate the long-term safety of avacopan in participants with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).

RGLS8429-02, RGLS8429 for ADPKD

Internal Medicine Nephrology Kidney Disease Adult Subjects

Primary Objectives

* To assess the safety and tolerability of RGLS8429
* To assess the impact of RGLS8429 on ADPKD biomarkers

Secondary Objectives

* To assess the impact of RGLS8429 on height-adjusted total kidney volume (htTKV)
* To characterize the pharmacokinetic (PK) properties of RGLS8429
* To assess the impact of RGLS8429 on renal function

417-201-00007, Sibeprenlimab, IgAN

Internal Medicine Nephrology Kidney Disease Adult Subjects

This is a phase 3 study to evaluate effects on proteinuria and glomerular filtration rate of sibeprenlimab 400 mg subcutaneously (s.c.) Q 4 weeks in adults with IgAN who are receiving maximally tolerated standard-of-care therapy.

Majesty Obinutuzumab in PM Nephropathy Study

Internal Medicine Adult Subjects

This study will evaluate the efficacy, safety, pharmacodynamics, and pharmacokinetics (PK) of obinutuzumab compared with tacrolimus in participants with primary membranous nephropathy (pMN).