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Christie Thomas

Internal Medicine

Studies

VX21-147-301, VX-147, for APOL1

Internal Medicine Nephrology Kidney Disease Pediatric Subjects Adult Subjects

The purpose of this study is to evaluate the efficacy, safety, tolerability, and pharmacokinetics (PK) of VX-147 in adult and pediatric participants with apolipoprotein L1 (APOL1)-mediated proteinuric kidney disease.

PRI-VENT

Internal Medicine Nephrology Kidney Disease Kidney Transplant Focal Segmental Glomerulosclerosis Pediatric Subjects Adult Subjects Female Subjects Male Subjects

This is a pilot/feasibility, multicenter, randomized, open label, clinical trial to test that hypothesis that plasmapheresis plus rituximab prior to or at the time of kidney transplantation can prevent recurrent FSGS in children and adults.