132-06, RSLV-132, for SS

Inclusion Criteria:
*  Providing written informed consent
*  Weight at least 45 kg
*  Meet the 2016 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) Classification Criteria for pSS
*  Diagnosis in the last 30 years
*  Positive anti-Ro/SSA antibody test
*  Score of 5 or higher on the EULAR Sjögren's Syndrome Patient Reported Index (ESSPRI) scale and the ESSPRI fatigue scale
*  Of non childbearing potential or of childbearing potential and using highly effective contraceptive measures

Exclusion Criteria:
*  Diagnosis of any active autoimmune disease other than pSS that could affect the efficacy assessments
*  Uncontrolled hypothyroidism or severe fibromyalgia
*  New medications or change in medications in the last 4 weeks for pSS symptoms
*  Receipt of other prohibited medications
*  Apheresis or blood donation
*  Allergic reaction to RSLV-132 or biologic therapy
*  Clinically significant infection in last 30 days
*  Participation in another clinical study
*  Malignancy in last 5 years
*  Positive test for HIV or hepatitis
*  Major surgery in last 30 days or anticipated surgery during the study
*  Pregnancy or breast feeding
*  Laboratory blood tests outside of specified ranges
*  Other medical conditions or medications that would make the participant unsuitable