Heart and Vascular

A Feasibility Study: A Safety Evaluation of the RheOx on Patients with Chronic Bronchitis in the United States

Anesthesia Internal Medicine Heart and Vascular Pulmonology Electrophysiology Lung Disease Adult Subjects Female Subjects Male Subjects

An early feasibility study (EFS) to assess the safety and clinical utility of RheOx on patients with chronic bronchitis in the United States.

ADVANCE Outcomes

Internal Medicine Pulmonology Heart and Vascular Pulmonary Hypertension Heart Disease Adult Subjects Female Subjects Male Subjects

Study ROR-PH-301, ADVANCE OUTCOMES, is designed to assess the efficacy and safety of ralinepag when added to pulmonary arterial hypertension (PAH) standard of care or PAH-specific background therapy in subjects with World Health Organization (WHO) Group 1 PAH.

Smoking Cessation and Functional CT Assessment

Cancer Radiology Pulmonology Heart and Vascular Pulmonary Hypertension Vascular Disease Airway Disease Heart Disease Healthy Subjects Adult Subjects Female Subjects Male Subjects

The investigators will study the effect of pulmonary arterial vasodilation to see if it eliminates indices of persistent lung injury in smokers that are susceptible to emphysema.

EP and psychophysics

Otolaryngology Heart and Vascular Electrophysiology Pediatric Subjects Adult Subjects Female Subjects Male Subjects

Effects of Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness (INCA) Study

Heart and Vascular Vascular Disease Healthy Subjects Adult Subjects Female Subjects Male Subjects

This study investigates the effect of dietary inorganic nitrate supplementation on 1) large elastic artery stiffness and hemodynamics and 2) cerebrovascular function in middle-aged and older adults. Participants will be randomized to consume either nitrate-containing or nitrate-depleted beetroot juice.

Evaluation of Transcatheter Aortic Valve Replacement Compared to Surveillance for Patients with Asymptomatic Severe Aortic Stenosis

Internal Medicine Heart and Vascular Valve Disease Adult Subjects

This study will evaluate the safety and effectiveness of the Edwards SAPIEN 3/SAPIEN 3 Ultra Transcatheter Heart Valve (THV) compared with clinical surveillance (CS) in asymptomatic patients with severe, calcific aortic stenosis.

Curcumin and vascular function in CKD

Internal Medicine Nephrology Heart and Vascular Kidney Disease Vascular Disease Heart Disease Adult Subjects Female Subjects Male Subjects

The proposed research is clinical study evaluating the therapeutic benefits of curcumin on vascular function in patients with chronic kidney disease (CKD). The study aims to establish that curcumin will improve endothelial function and reduce large artery stiffness by reducing oxidative stress and in conjunction with lowering markers of inflammation and oxidative stress. In addition, the study will evaluate the potential benefit of curcumin on cognitive function in patients with CKD.

A Randomized Controlled Trial Evaluating the Effect of the Oxytocin Infusion Rate on Fetal Heart Rate Changes and Maternal Fetal Outcomes during the Initiation of Combined Spinal-Epidural Labor Analgesia

Anesthesia Heart and Vascular Electrophysiology Healthy Subjects Adult Subjects Female Subjects

The reported risk of nonreassuring fetal heart trace following neuraxial analgesia is 3-23%. This variability may be due to fluid and oxytocin management prior to and during the initiation of neuraxial analgesia. The study hypothesis is that decreasing the oxytocin infusion rate by 50 % prior to initiation of combined spinal epidural analgesia will cause a reduction in the incidence of adverse fetal heart rate changes.

PH Genetics

Internal Medicine Heart and Vascular Heart Disease Pediatric Subjects Adult Subjects Female Subjects Male Subjects

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