HPV Functional CT Assessment

Radiology Pulmonology Infectious Disease Heart and Vascular Airway Disease Viral Infectious Diseases Lung Disease Vascular Disease Healthy Subjects Adult Subjects Female Subjects Male Subjects

This study will use dual energy x-ray computed tomography (DECT) to evaluate the relationship between heterogeneous perfusion, hypoxia (low oxygen in inspired gas) and induction of pulmonary vascular dilatation to characterize emphysema susceptibility in a normal smoking population. The investigators will correlate DECT measures of perfusion with lung injury measured by single photon emission computed tomography (SPECT). The investigators will study the effect of pulmonary arterial vasodilation to see if it eliminates indices of persistent lung injury in smokers that are susceptible to emphysema

One Stage versus Two Stage For Periprosthetic Hip And Knee Infection

Orthopedics Infectious Disease Infectious Disease Adult Subjects Female Subjects Male Subjects

The purpose of this study is to compare the outcomes of two different treatment options commonly used to manage periprosthetic joint infection (PJI), an infection around the artificial knee or hip.