RNA Expression Based Biomarkers of Brain Aneurysm
Neurology
Adult Subjects
Clinical Research and Trials
Neurology
SMASH!
Neurology
Adult Subjects
Female Subjects
Male Subjects
Post-Market Surveillance Study to Evaluate the Long-Term Safety and Effectiveness of the WEB® Device (WEB-PAS)
Neurology
Adult Subjects
A prospective, multicenter, single arm, interventional study. The target patient population for this study are adult subjects with WNBAs of the anterior and posterior intracranial circulation. The primary effectiveness outcome of the study is adequate intracranial aneurysm occlusion on the 1 year angiogram as adjudicated by a core laboratory.
Flow Re-Direction Endoluminal Device X (FRED X) Post-Approval Study
Neurology
Adult Subjects
The objective of this study is to generate contemporaneous clinical data to facilitate a reasonable comparison of the performance of the FRED™ X™ device with the performance of the FRED™ device. The data generated from this study will be compared to the safety and effectiveness of the FRED™ device by meeting the same performance goals (PGs) established for the FRED™ pivotal study.
Post-Approval Study Post-Market Surveillance Study to Evaluate the Long-Term Safety and Effectiveness of the LVIS® Device
Neurology
Adult Subjects
Parkinsons Foundation PD GENEration Genetic Registry
Neurology
Adult Subjects
Female Subjects
Male Subjects
UI-BRAIN: Biomarker Registry of Autoimmune and Inflammatory Neurologic Diseases
Neurology
Immunology
Autoimmune
Pediatric Subjects
Adult Subjects
Female Subjects
Male Subjects
Left Atrial Appendage Occlusion with WATCHMAN FLX device vs. Blood Thinning Medication to Prevent Stroke occurrence with Atrial Fibrillation
Internal Medicine
Neurology
Stroke
Electrophysiology
Adult Subjects
Dystonia Coalition Projects-3
Neurology
Pediatric Subjects
Adult Subjects
Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on Recovery (DISCOVERY)
Neurology
Stroke
Vascular Disease
Adult Subjects
The overall goal of the DISCOVERY study is to better understand what factors contribute to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced a stroke. The purpose of the study is to help doctors identify patients at risk for dementia (decline in memory, thinking and other mental abilities that significantly affects daily functioning) after their stroke so that future treatments may be developed to improve outcomes in stroke patients. For this study, a "stroke" is defined as either (1) an acute ischemic stroke (AIS, or blood clot in the brain), (2) an intracerebral hemorrhage (ICH, or bleeding in the brain), (3) or an aneurysmal subarachnoid hemorrhage (aSAH, or bleeding around the brain caused by an abnormal bulge in a blood vessel that bursts).
The investigators hypothesize that:
1. The size, type and location of the stroke play an important role in recovery of thinking and memory abilities after stroke, and pre-existing indicators of brain health further determine the extent of this recovery.
2. Specific stroke events occurring in individuals with underlying genetic or biological risk factors can cause further declines in brain heath, leading to changes in thinking and memory abilities after stroke.
3. Studying thinking and memory alongside brain imaging and blood samples in patients who have had a stroke allows for earlier identification of declining brain health and development of individualized treatment plans to improve patient outcomes in the future.