ANHL1931: A study combining nivolumab and chemo-immunotherapy as a treatment option for Primary Mediastinal B-cell lymphoma (PMBCL)

Cancer Pediatrics Radiology Lymphoma Pediatric Subjects Adult Subjects

This phase III trial compares the effects of nivolumab with chemo-immunotherapy versus chemo-immunotherapy alone in treating patients with newly diagnosed primary mediastinal B-cell lymphoma (PMBCL). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of cancer cells to grow and spread. Treatment for PMBCL involves chemotherapy combined with an immunotherapy called rituximab. Chemotherapy drugs work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Rituximab is a monoclonal antibody. It binds to a protein called CD20, which is found on B cells (a type of white blood cell) and some types of cancer cells. This may help the immune system kill cancer cells. Giving nivolumab with chemo-immunotherapy may help treat patients with PMBCL.

EA1151- Tomosynthesis Mammographic Imaging Screening Trial(TMIST)

Cancer Radiology Breast Cancer Healthy Subjects Adult Subjects

This randomized phase III trial studies digital tomosynthesis mammography and digital mammography in screening patients for breast cancer. Screening for breast cancer with tomosynthesis mammography may be superior to digital mammography for breast cancer screening and may help reduce the need for additional imaging or treatment.

ECOG ACRIN EA8171: Multiparametric MRI (mpMRI) for Preoperative Staging and Treatment Planning for Newly-Diagnosed Prostate Cancer

Cancer Pathology Radiology Immunology Prostate Cancer Immunodeficiency Adult Subjects

This phase II trial studies how well multiparametric magnetic resonance imaging (MRI) works in evaluating cancer stage and helping treatment planning in patients with prostate cancer. Multiparametric MRI may be useful for evaluating the type of cancer in finding aggressive disease.

HPV Functional CT Assessment

Radiology Pulmonology Infectious Disease Heart and Vascular Airway Disease Viral Infectious Diseases Lung Disease Vascular Disease Healthy Subjects Adult Subjects Female Subjects Male Subjects

This study will use dual energy x-ray computed tomography (DECT) to evaluate the relationship between heterogeneous perfusion, hypoxia (low oxygen in inspired gas) and induction of pulmonary vascular dilatation to characterize emphysema susceptibility in a normal smoking population. The investigators will correlate DECT measures of perfusion with lung injury measured by single photon emission computed tomography (SPECT). The investigators will study the effect of pulmonary arterial vasodilation to see if it eliminates indices of persistent lung injury in smokers that are susceptible to emphysema

Smoking Cessation and Functional CT Assessment

Cancer Radiology Pulmonology Heart and Vascular Pulmonary Hypertension Vascular Disease Airway Disease Heart Disease Healthy Subjects Adult Subjects Female Subjects Male Subjects

The investigators will study the effect of pulmonary arterial vasodilation to see if it eliminates indices of persistent lung injury in smokers that are susceptible to emphysema.

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