MK5475-013

The key inclusion and exclusion criteria include but are not limited to the following: Inclusion Criteria:
*  Has Group 3.1 pulmonary hypertension chronic obstructive pulmonary disease (PH-COPD) as defined by the Clinical Classification of Pulmonary Hypertension.
*  Has a right heart catheterization (RHC) at screening or historical RHC within 12 months before screening that meets hemodynamic criteria.
*  Has a physician diagnosis of obstructive lung disease on pulmonary function testing (PFT) performed at screening.
*  Has a WHO Functional Class assessment of Class II to IV.
*  If on supplemental oxygen, the regimen must be stable.
*  Has stable and optimized chronic, baseline COPD-specific therapy.
*  If on PDE5 inhibitor, has stable concomitant use (initiated at least 3 months prior to randomization and no change in drug or dosage for at least 3 months prior to randomization) and changes to PDE5 inhibitor dosing is not anticipated during the 24 week Base Period.
*  If on antihypertensives and/or a diuretic regimen has stable concomitant use.
*  If on anticoagulants has stable concomitant use.
*  Is of any sex/gender from 40 to 85 years of age inclusive.
*  Female is not pregnant or breastfeeding, and is not of childbearing potential or uses acceptable contraceptive method or abstains from sexual intercourse, or has a negative highly sensitive pregnancy test within 24 hours before the first dose of study intervention, or whose history and sexual activity has been reviewed by the investigator.

Exclusion Criteria:
*  Has Group 1 pulmonary arterial hypertension (PAH), Groups 2, 4 or 5 pulmonary hypertension (PH).
*  Has non-COPD related Group 3 PH.
*  Has evidence of untreated more than mild obstructive sleep apnea.
*  Has significant left heart disease.
*  Expects to receive a lung and/or heart transplant from screening through the end of the 24 week Base Period.
*  Has evidence of a resting oxygen saturation (SpO2) \< 88%.
*  Has experienced a moderate or severe COPD exacerbation within 2 months before randomization.
*  Has experienced right heart failure within 2 months before randomization.
*  Has uncontrolled tachyarrhythmia.
*  Has acute coronary syndrome, undergone coronary artery bypass graft, or percutaneous coronary intervention within 2 months before randomization.
*  Has evidence of significant chronic renal insufficiency.
*  Has evidence of chronic liver disease, portal hypertension, cirrhosis, or hepatic abnormalities.
*  Initiated a pulmonary rehabilitation program within 2 months before randomization.
*  Has impairments that limit the ability to perform 6MWT.
*  Has history of cancer.
*  Is a user of illicit drugs or has a recent history of drug/alcohol abuse or dependence.
*  Has used PAH-specific therapies within 2 months of randomization.