VX24-407-101, VX-407, ADPKD PKD1 Gene

Key Inclusion Criteria:
*  A pre-existing diagnosis of ADPKD as defined in the protocol
*  Willing and able to comply with scheduled visits and other study procedures
*  Participants with ADPKD with Mayo imaging classification (MIC) status of 1B (with htTKV ≥250 mL/m), 1C, 1D, or 1E confirmed by abdominal MRI obtained during screening
*  Estimated glomerular filtration rate (eGFR) greater than or equal to (≥) 25 milliliter per minute (mL/min)/1.73 square meter (m\^2)

Key Exclusion Criteria:
*  History of kidney disease other than ADPKD that in the opinion of the investigator would independently impact the natural history of ADPKD
*  History of solid organ or bone marrow transplantation or nephrectomy
*  Ongoing renal replacement therapy or planning to start renal replacement therapy within 12 months of screening Other protocol defined Inclusion/Exclusion criteria will apply.